MEDICINAL CHEMISTRY Complete syllabus

  

PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY) (Theory)

Paper 1                                                                                                                                                                                                        Marks 100

 

NOTE: The topics will be taught with special reference to their Pharmaceutical Applications.

 

1.     INTRODUCTION TO MEDICINAL CHEMISTRY: Chemical constitution and biological activity: (Receptor, Theory, Structure Activity Relationships (SAR) and Drug Metabolism).

Modern concept of rational drug design, pro drug, combinatorial chemistry and computer aided drug design (CADD) and concept of antisense molecules.

 

2.     DRUG TARGETS AND DRUG DESIGNING:

a)     Introduction and types of drug targets

b)    Introduction to molecular modeling and computational chemistry

c)     Structure based designing

d)    Ligand-based designing

e)     Various techniques in drug synthesis

3.     GENERAL PROPERTIES, CHEMISTRY, BIOLOGICAL ACTION, STRUCTURE ACTIVITY RELATIONSHIP AND THERAPEUTIC APPLICATIONS OF THE FOLLOWING:

a.     Hormones: Steroidal Hormones (Testosterone, Progesterone, Estrogen, Aldosteron and Cortisol), Proteinous Hormones (Insulin, Glucagon, Oxytocin and Vassopressin).

b.     Anti-neoplasticAgents:           Tamoxifen,             Fluorouracil,   Mercapturine, Methotrexate             and Vincristine.

c.     Sedatives and Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde, Glutethimide, Chloral hydrate, and alcohols.

d.     Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine, Cocaine and Benzocaine), General anaesthetics (Cyclopropane, Halothane, Nitrous oxide, Chloroform, Thiopental

Sodium, Ketamine, Methohexital, Thioamylal Sodium, Fantanyl Citrate, Tribromo ethanol).

e.     Analgesics and Antipyretics: Paracetamol, Salicylic acid analogues, Quinolines derivatives, Pyrazolone and Pyrazolodiones, N - arylanthranilic acids, Aryl and heteroaryl acetic acid derivatives.

f.      Sulphonamides:          Prontosil,         sulphanilamide,             Sulphapyridine,           sulphadimidine, Sulfamethoxazole, Sulfadiazine and Sulfafurazole.

g.     Antimalarials: 4-Aminoquinolines, 8-Aminoquinolines, 9-Amino acridines, Biguanides, Pyrimidine analogues, Mefloquine and Cinchoha alkaloids.

h.     Diuretics: Mercaptomerin, Meralluride, Thiazides, Sprironolac-tone, Theophylline, Furosemide, Acetazolamiode, Ethacrynic acid and Triameterene.

i.      Antitubercular Drugs: Ethambutol, Isonicotinic acid, Hydrazid, Rifampacin, Thioguanine, Pyrazinamide, cycloserine, Ethunamide, Cytarabine, 5-Flourouracil and Dacarbazine.

j.      Antiviral Drugs: Acyclovir, Tromantadine Hydrochloride and Ribavirin.

k.     Immunosuppressant Agents: Azathioprine and Cyclosporin.

Antibiotics: Penicillins, Cephalosporins, Streptomycin, Chloramphenicol, Tetracyclines, Kanamycin and Erythromycin.