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PHARMACEUTICS-VII
(PHARMACEUTICAL TECHNOLOGY) (Theory) |
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Paper 3 |
Marks 100 |
1.
PRINCIPLES OF PHARMACEUTICAL
FORMULATION AND DOSAGE FORM DESIGN:
Need
for dosage form; Pre-formulation Studies; Product Formulation.
2.
ADVANCED GRANULATION TECHNOLOGY
(DESIGN & PRACTICE):
Spray Drying Granulation Technology; Roller
Compaction Technology; Extrusion/Spheronization as a Granulation Technique;
Single-Pot Processing Granulation
Technology: Rapid Release Granulation Technique; Particle Coating by
Centrifugation Granulation Technology.
3.
POLYMERS USED IN DRUG DELIVERY
SYSTEMS:
4.
NOVEL DRUG DELIVERY SYSTEM (DDS):
Sustained/ Controlled Release Drug
Delivery System
i. Microencapsulation technique
• Coacervation
• Solvent evaporation
• Interfacial polymerization
• Spray drying ii.
Developmental aspects of Matrix and
Reservoir Systems
5.
NOVEL GIT DRUG DELIVERY SYSTEM
(DDS): Oral Osmotic Pumps
• Ion-Exchange Controlled DDS
• pH-Controlled DDS
• Bio/mucoadhesive DDS
• Floating DDS
6.
DRUG CARRIER SYSTEM:
Liposomes
Niosomes
7.
TARGETED DRUG DELIVERY SYSTEM:
• Active Drug Delivery System
• Passive Drug Delivery System
8.
PHARMACEUTICAL BIOTECHNOLOGY:
a.
Introduction to Biotechnology:
Genetics/Genomics, Proteomics, Biomolecular target Identification,
Pharmacogenomics, Gene therapy and Nucleic acid therapeutics.
b.
Techniques Used in
Pharmaceutical biotechnology: PCR, DNA Sequencing, Affinity Protein
Purification.
c.
Fundamentals of Genetic
Engineering and its Application in Medicine
d.
Pharmaceutical Recombinant
therapeutic Proteins, Growth factors, Therapeutic antibodies, High-throughput
screening of putative therapeutic compounds.
e.
Biotechnological aspects in the
product development
f.
Principle, Synthesis and
Application of Monoclonal Antibodies
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