Skip to main content

Contact Us

 Be assured each email is received to us, read & taken very seriously. However, due to huge amount of emails, we may reply only those emails that really require response from doctorofpharmacyy

You can email us at doctorofpharmacyy@gmail.com

Comments

  1. A salam kia hal ha sir ye joo notes kha is koo ham photostate nahi kr sakte ak option is ka be hona chahie

    ReplyDelete

Post a Comment

Popular posts from this blog

MEDICINAL CHEMISTRY Complete syllabus

    PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY) (Theory) Paper 1                                                                                                                                                         ...

Melanocyte Stimulating Hormone (MSH)

    Melanocyte Stimulating Hormone (MSH) •     Secreted by Pars inermedia (intermediate lobe) of pituitary •     Occurs in three different forms (α, β, and γ MSH) •     Biosynthesis: – MSH is the cleavage product of a large precursor peptide called pro-opiomelano cortin (POMC) •     Protease enzyme cleave POMC into ACTH and βlipotropin •     ACTH is further cleaved to form MSH   •     Mechanism: •     Act by binding the G-protein coupled melanocortin 1 receptor (MC1R) on melanocytes – Increases cAMP levels through adenylyl cyclase •     Functions of MSH: •     Stimulate the production and release of melanin from melanocytes in skin & hair (melanogenesis) –   Darkens the skin •     α-MSH acts on hypothalamus –   Suppresses appetite –   Arouse sexually     ...

Adrenocorticotropin

   Adrenocorticotropin •     Also called Adrenocorticotropic Hormone (ACTH) , corticotropin •     Concerned with the growth and functioning of adrenal cortex •     Chemistry: – Single polypeptide with 39 aminoacids •     First 23 amino acids from N-terminal contains biological activity –   Molecular weight 4500 –   Occurs in two forms •      α-corticotropin •      β-corticotropin •      ACTH is synthesized from a glycoprotein called Proopiomelano cortin (POMC) peptide •      POMC is hydrolyzed by different enzymes to form: –   ACTH –   β-Lipotropin –   β-Endorphins  –   Melanocyte Stimulating Hormone (MSH) etc. •     Mechanism of Action •     Ca 2+ ion dependant activation of cAMP – Increased transcription and translation •  ...