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About Us

 This is an Educational blog.

In this blog we share Doctor of pharmacy 5 years cotent i.e. Slides, Notes, books,practicals all other related material.

This blog is related to pharmacy or medical students.

We provide 

some basic knowladge 

some medium knowladge

and some high level things hare.

you can also submit your notes for public view.

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MEDICINAL CHEMISTRY Complete syllabus

    PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY) (Theory) Paper 1                                                                                                                                                         ...

Melanocyte Stimulating Hormone (MSH)

    Melanocyte Stimulating Hormone (MSH) •     Secreted by Pars inermedia (intermediate lobe) of pituitary •     Occurs in three different forms (α, β, and γ MSH) •     Biosynthesis: – MSH is the cleavage product of a large precursor peptide called pro-opiomelano cortin (POMC) •     Protease enzyme cleave POMC into ACTH and βlipotropin •     ACTH is further cleaved to form MSH   •     Mechanism: •     Act by binding the G-protein coupled melanocortin 1 receptor (MC1R) on melanocytes – Increases cAMP levels through adenylyl cyclase •     Functions of MSH: •     Stimulate the production and release of melanin from melanocytes in skin & hair (melanogenesis) –   Darkens the skin •     α-MSH acts on hypothalamus –   Suppresses appetite –   Arouse sexually     ...

Adrenocorticotropin

   Adrenocorticotropin •     Also called Adrenocorticotropic Hormone (ACTH) , corticotropin •     Concerned with the growth and functioning of adrenal cortex •     Chemistry: – Single polypeptide with 39 aminoacids •     First 23 amino acids from N-terminal contains biological activity –   Molecular weight 4500 –   Occurs in two forms •      α-corticotropin •      β-corticotropin •      ACTH is synthesized from a glycoprotein called Proopiomelano cortin (POMC) peptide •      POMC is hydrolyzed by different enzymes to form: –   ACTH –   β-Lipotropin –   β-Endorphins  –   Melanocyte Stimulating Hormone (MSH) etc. •     Mechanism of Action •     Ca 2+ ion dependant activation of cAMP – Increased transcription and translation •  ...