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PHARMACOGNOSY-II (ADVANCED) (Theory) |
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Paper 3 |
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Marks
100 |
1. SEPARATION
AND ISOLATION OF PLANT CONSTITUENTS: Introduction and use of
spectroscopic and chromatographic techniques for the identification of natural
products.
Description and interpretation of ultraviolet,
infrared, mass, nuclear magnetic resonance (1H-NMR and 13C-NMR)
and other advance techniques to elucidate the structure of natural products.
2. CARBOHYDRATES
AND RELATED COMPOUNDS: Introduction and classification of
carbohydrates, sugars as adjuvant in drugs, role of impurities in sugar
substances.
(a)
Sucrose and
Sucrose containing drugs: Sucrose, Dextrose, Liquid glucose, Fructose,
Lactose, Xylose, Caramel, Starch, Inulin, Dextrine etc.
(b)
Cellulose and
Cellulose Derivatives: Powdered cellulose, microcrystalline cellulose,
Methyl cellulose, Sodium Carboxy-methyl cellulose.
(c)
Gums and
Mucilage: Tragacanth, Acacia, Sodium Alginate, Agar, Pectin.
3. ALKALOIDS:
Introduction, Properties, Classification, Function of alkaloids in plants,
Methods of extraction and identification tests.
(a)
Pyridine
Piperidine Alkaloids: Areca nut, Lobelia.
(b)
Tropane
Alkaloids: Belladonna, Hyoscyamus, Stramonium.
(c)
Quinoline
Alkaloids: Cinchona.
(d)
Isoquinoline
Alkaloids: Ipecacuanha, Opium.
(e)
Indole
alkaloids: Rauwolfia, Catharanthus, Nux vomica, Physostigma, Ergot.
(f)
Imidazole
alkaloids: Pilocarpus.
(g)
Steroidal
alkaloids: Veratrum.
(h)
Alkaloidal
amines: Ephedra, Colchicum. (i) Purine Bases: Tea, Coffee.
4. GLYCOSIDES:
Introduction, classification, chemistry, extraction, isolation and
medicinal uses of:
(a) |
Cardioactive
glycosides: |
Digitalis,
Strophanthus and white squill. |
(b) |
Anthraquinone
glycosides: |
Cascara, Aloe, Rhubarb, Cochineal and Senna. |
(c) |
Saponin glycosides: |
Glycyrrhiza, Sarsaparilla. |
(d) |
Cyanophore glycosides:
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Wild cherry. |
(e) |
Isothiocyanate
glycosides: |
Black mustard. |
(f) |
Lactone glycosides: |
Cantharide. |
(g) |
Aldehyde glycosides: |
Vanilla. |
(h) |
Miscellaneous
glycosides: |
Gentian, Quassia, Dioscorea. |
5. PLANT
STEROIDS: Introduction, extraction, isolation, nomenclature, sources
and uses of bile acids, plant sterols, steroidal sapogenins, steroid hormones,
withanolides and ecdysons.
6. LIPIDS:
Introduction, classification, source, active constituents and
pharmacological uses of:
(a) Fixed Oils: Castor oil, Cotton seed oil, olive
oil, Peanut oil, Sun flower oil, Corn oil, Coconut oil, Almond oil, Linseed
oil, Mustard oil, Sesame oil and Soybean oil.
(b) Fats and Related Compounds: Theobroma oil and
Lanolin.
(c) Waxes: Bees wax, carnauba wax, spermaceti and
Jojoba oil.
7. VOLATILE
OILS (ESSENTIAL OILS): Introduction, significance, sources, active
constituents, methods of obtaining volatile oils, chemistry and classification
of:
(a) Hydrocarbon volatile oils: Cubeb and
Turpentine oil.
(b) Alcoholic volatile oils: Peppermint, Coriander
and Cardamom.
(c) Aldehydic volatile oils: Bitter orange peel,
Sweet orange peel, Lemon Cinnamon and Bitter almond oil
(d) Ketonic volatile oils: Camphor, Spearmint, Caraway,
Buchu
(e) Phenolic volatile oils: Clove, Thyme.
(f) Phenolic ether volatile oils: Fennel, Anise,
Myristica.
(g) Oxide volatile oils: Eucalyptus, Chenopodium.
(h) Ester volatile oils: Rosemary.
(i) Miscellaneous volatile oils: Allium, Anethum.
8. RESINS AND
OLEORESINS: Introduction, classification, active constituents and
pharmacological uses of jalap, turpentine, asafoetida, benzoin, rosin,
cannabis, podophyllum, ipomea, myrrh, and balsam.
9. TANNINS:
Introduction, classification, biosynthesis, extraction, identification,
occurrence in plants, role in plant life and chemical study of tannins in Kino, Myrobalan, Catechu, Nutgall,
Castanea and krameria.
10. NATURAL
TOXICANTS:
a) General Introduction to Plant Toxicology:
Definition, classification and chemical nature of plant toxins. Plant toxicities in humans and animals
b) Higher Plant Toxins: Essential oils: Terpene
(cineol, pine oil), Phenyl propane (apiol, safrole, myristicin), Monoterpene
(thujone, menthafuran) Plant acids (oxalic acid, amino acid, resin acid),
Glycosides (cardiotonic, cyanogenic), Alkaloids (imidazole, pyrrolizidine,
tropane).
c) Lower Plant Toxins: Bacterial toxins
(Staphylococcus aureus, Clostridium botulinum), Algal toxins (Microcystis
aeruginosa, Cyanobecteria, Gonyaulax cantenella).
d) Mycotoxins: Fungal toxins (Aspergillus spp.,
Claviceps purpurea), Mushrooms (Amanita spp.).
e) Study of Toxins, their Prevention and Control
Methods: Description, pharmacognostic features, pharmacological actions,
chemical constituents, treatment, side-effects, contra-indications, warnings,
prevention and control methods of Abrus precatorius, Papaver somniferum,
Eucalyptus spp., Nicotiana tabaccum, Cannabis sativa, Digitalis purpurea,
Datura stramonium etc. poisoning.
11. AN
INTRODUCTION TO NUTRACEUTICALS AND COSMECEUTICALS:
12. TUMOUR
INHIBITORS FROM PLANTS: Introduction of anticancer agents of natural
origin, as Catharanthus roseus, Colchicum autumnale, Podophyllum peltatum,
rifamycin antibiotics, macrolide antibiotics, anti-AIDS agents and
immunostimulants.
13. INTRODUCTION
TO CLINICAL PHARMACOGNOSY: General introduction and
historical background of clinical Pharmacognosy.
Study of treatment by herbal medicines.
14. CLINICAL
USE OF HERBS & HERBAL MEDICINE:
Diabetes: |
Gymnema
sylvestre, Melia azadirchta, Momordica charantia, Syzygium jambulana. |
Cardiac diseases: |
Digitalis spp.,
Convallaria majalis, Urgenia indica, Allium sativum, Punica granatum. |
Hepatitis: |
Berberis
vulgaris, Picrorhiza kurroa, Lawsonia in. |
Respiratory
diseases: |
Ficus religosa,
Adhatoda vasica. |
Skin diseases: |
Aloe vera,
Angelica archangelica, Mentha piperita, Citrus spp., Commiphora mukul. |
CNS disorders: |
Strychnos
nux-vomica, Datura stramonium, Cannabis sativa, Papaver somniferum, Atropa
belladonna. |
Musculo-skeletal disorders: |
Nigella sativa,
Phycotis ajowan, Trigonella foenum-graecum, Zingiber officinale. |
Renal disorders: |
Cucumis melo, Berberis vulgaris, Zea mays,
Tribulus terrestris. |
Reproductive disorders:
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Saraca indica,
Ruta graveolens, Nigella sativa, Glycyrrhiza glabra, Claviceps purpurea,
Myristica fragrance. |
G.I.T. disorders: |
Foeniculum
vulgare, Ferula foetida, Cuminum cyminum, Aegle marmelos, Prunus domestica. |
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PHARMACOGNOSY-II (ADVANCED) (Practical) |
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Paper 9 |
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Marks
100 |
NOTE: Practical of the subject shall be designed from time to time
on the basis of the above mentioned theoretical topics and availability of the
facilities, e.g. Extraction of the active constituents of crude drugs and
chemical tests for their identification. Isolation and separation of active
constituents of crude drugs by paper and thin layer chromatography.
Also include the following experiments;
•
Determination of Iodine value; Saponification
value and unsaponifiable matter; ester value; Acid value.
•
Chemical tests for Acacia, Tragacanth, Agar,
Starch, Lipids, (Castor oil, Sesame oil, Shark liver oil, Bees wax), Gelatin.
(Note: A minimum of 20 practicals will be
conducted).
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