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PHARMACOLOGY AND THERAPEUTICS-II (Theory) Paper 2 |
Marks
100 |
1. DRUGS
ACTING ON CENTRAL NERVOUS SYSTEM:
(a)
Sedatives & Hypnotic
(b)
Anxiolytics, antidepressants and anti-manic
drugs (c) Antiepileptics
(d)
Antiparkinsonian and drug used in other
neurodegenerative diseases.
(e)
Antipsychotics
(f)
Opioid analgesics
(g)
Therapeutic gases (Oxygen, Carbon-dioxide,
Nitric oxide and Helium.
(h)
Cerebral Stimulants, Medullary stimulants,
Spinal Cord Stimulants (i) Anesthetics:
General and local
2. NON-STEROIDAL
ANTI-INFLAMMATORY DRUGS: Disease modifying antirheumatic drugs, non-
opioid analgesics and drugs used in the treatment of gout.
3. CHEMOTHERAPY
•
Basic principles of chemotherapy
•
Antibacterials (Folate antagonists
:sulphonamides, Cell wall synthesis inhibitors; Penicillin, Cephalosporins,
Carbapenam, Monobactam, Protein synthesis inhibitors; Aminoglycosides,
Tetracyclines, Chloramphenicol, Macrolides, Nucleic acid synthesis inhibitors;
Quinolones and miscellaneous Antibiotics), Anti-mycobacterial drugs, Urinary
tract antiseptics,
•
Anti-fungals
•
Anti-virals
•
Anti-protozoals: anti-malarias, anti-amebiasis,
anthelmintics and anti-leishmanials.
•
Anti-neoplastic drugs
4. IMMUNOPHARMACOLOGY:
Pharmacology of immune-suppressants and stimulants
5. TOXICOLOGY
(a)
Pollution and its types (water, air, food)
(b)
Poison and principle of treatment of poisoning.
(c)
Poisoning (Sign & symptom and treatment):
Ethanol, Barbiturates, Digitalis, Salicylates, Strychnine, Narcotics,
Nicotine, Paracetamol, Benzodiazepines and Organophosphorous
compounds.
(d)
Chelating agents and their role in poisoning:
Dimercaprol, Calcium disodium Edetate
(Calcium EDTA), Pencillamine and Defroxamine.
NOTE:
1.
Only an introduction will be given of the banned
and obsolete drug products.
2.
While dealing with Pharmacology stress should be
laid to the group actions of related drugs and only important differences
should be discussed of the individual drugs placed in same group.
3.
Newly introduced drugs should be included in the
syllabus while drugs with no clinical and therapeutic values ought to be
excluded from syllabus at any time.
4.
The prototype drugs in each group from the
latest edition
of the recommended books.
PHARMACOLOGY AND THERAPEUTICS-II (Practical)
Paper 8 Marks 100
NOTE: Practical
of the subject shall be designed from time to time on the basis of the above
mentioned theoretical topics and availability of the facilities, e.g.
• To
study the convulsant effects of strychnine and picrotoxin in frogs and to
determine the site of action.
• To
identify the unknown (convulsant) drug and determine its site of action.
• To
study the effects of Adrenaline on Human Eyes.
• To
study the effects of Pilocarpine on Human Eyes.
• To
study the effect of Homatropine on Human Eyes.
• To
identify and observe the effects of unknown drugs on Human Eyes.
• To
study the effects of local anaesthetic drugs on human and the nerve plexus of
frog.
• To
identify and differentiate the effects of unknown drug on human and the nerve
plexus of frog.
• To
demonstrate the effects of Acetylcholine on the Rectus abdominus muscle of frog
and competitive pharmacological antagonism by Neuromuscular blocking agent e.g.
Gallamine.
• To
identify the unknown drug by performing pharmacological competitive antagonism
on Rectus abdominus muscle of Frog.
• To
study the anti-coagulant effects of Heparin and oral anti-coagulants on
Rabbits.
• To
identify the unknown anticoagulant drug using Rabbits.
• To
demonstrate the Graded Dose-Response curve of Acetylcholine on Rabbit
intestine.
• To
identify unknown concentration of Acetycholine from Graded Dose Response
curves.
• To
demonstrate the general anesthetic effect on rabbits.
• To
demonstrate the effect of sedatives and hypnotics on rabbits.
• To
demonstrate the anti-nociceptive (analgesic) effect on mice.
• To
demonstrate antidepressant effect in rats (forced swimming test, tail
suspension test Yohimbin lethality test).
(Note: A minimum of 20
practicals will be conducted).
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