Organic chemistry -PHARMACEUTICAL CHEMISTRY-I syllabus

 

 

 

PHARMACEUTICAL CHEMISTRY-I (ORGANIC) (Theory)

Paper 1                                                                                                                                                                                                                                                                                                                     Marks 100

 

NOTE: The topics will be taught with special reference to their Pharmaceutical Applications.

 

1.     BASIC CONCEPTS: Chemical Bonding and concept of Hybridization, Conjugation, Resonance (Mesomerism), Hyperconjugation, Aromaticity, Inductive effect, Electromeric effect, Hydrogen bonding, Steric effect, Effect of structure on reactivity of compounds, Tautomerism of Carbonyl Compounds, Nomenclature of Organic Compounds.

 

2.     STEREOCHEMISTRY/CONFORMATIONAL ANALYSIS: Stereoisomerism, optical isomerism; Molecules with more than one chiral center Geometrical isomerism, Resolution of racemic mixture, Conformational analysis.

3.     GENERAL METHODS OF PREPARATION, PROPERTIES, IDENTIFICATION TEST AND PHARMACEUTICAL APPLICATIONS OF THE FOLLOWING CLASSES AND THEIR ANALOGUES:

a.       Alkane, Alkenes, Alkynes, Aromatic compounds

b.       Alkyl halide, Alcohol, phenols, ethers, amines

c.       Ketones, Aldehydes

d.       Acids, Esters, Amides and derivatives

 

4.     NUCLEOPHILIC, ELECTROPHILIC SUBSTITUTION REACTION IN ALIPHATIC AND AROMATIC SYSTEMS:

5.     ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON BENZENE RING:

6.     HETEROCYCLIC CHEMISTRY:

a.       Preparation and properties of medicinally important Heterocyclic Compounds such as pyrol, furan, thiophene, pyridine, pyrimidine and pyrazine.

b.       Preparation and properties of hetrocyclic compounds in which benzo-ring is fused with five and six membered ring containing one hetero atom; Indole, Quinoline and Isoquinoline.

 

7.     REACTION MECHANISM:

Organic Reaction Mechanism:  Arndt-Eistert reaction, Baeyer-Villiger oxidation, Diels Alder reaction; Grignard’s reaction, Metal Hydride reduction and Wolff Kishner reduction, Friedel Craft’s reaction, Perkin reaction, Cannizzaro’s reaction, Mannich reaction.

8.     REACTIVE INTERMEDIATE AND FREE RADICALS:

a.       Introduction: Generation, stability and reaction of the following Intermediates;

Carbocations, Carbanions, Carbenes, Nitrenes, Benzynes,

b.       Types of reactions: An Overview.

c.       Free radicals: Free radical scavengers and their applications.

 

9.     CARBONIUM ION REARRANGEMENTS:

Pinacol-Pinacolone, Wagner-Meerwein, Wolff, Hofmann and Beckmann rearrangements.

 

10.  CARBANIONS REARRANGEMENTS:

Condensation reaction (Aldol condensation, Favorskii rearrangement, Wittig rearrangement).

 

PHARMACEUTICAL CHEMISTRY-I (ORGANIC) (Practical)

Paper 7                                                                                                                                                                                                                                                                                                                     Marks 100

 

NOTE: Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1.       Organic analysis: Identification of unknown simple organic compounds.

2.       Organic Preparations: Benzoic acid, Aspirin, Acetanilide, Iodoform, Nitrophenol, 3nitrophthalic acid, Benzhydrol and 2, 4-Dinitrochlorobenzene.